Nature Communications (Aug 2018)
Linked dimensions of psychopathology and connectivity in functional brain networks
- Cedric Huchuan Xia,
- Zongming Ma,
- Rastko Ciric,
- Shi Gu,
- Richard F. Betzel,
- Antonia N. Kaczkurkin,
- Monica E. Calkins,
- Philip A. Cook,
- Angel García de la Garza,
- Simon N. Vandekar,
- Zaixu Cui,
- Tyler M. Moore,
- David R. Roalf,
- Kosha Ruparel,
- Daniel H. Wolf,
- Christos Davatzikos,
- Ruben C. Gur,
- Raquel E. Gur,
- Russell T. Shinohara,
- Danielle S. Bassett,
- Theodore D. Satterthwaite
Affiliations
- Cedric Huchuan Xia
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Zongming Ma
- Department of Statistics, The Wharton School, University of Pennsylvania
- Rastko Ciric
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Shi Gu
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Richard F. Betzel
- Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania
- Antonia N. Kaczkurkin
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Monica E. Calkins
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Philip A. Cook
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania
- Angel García de la Garza
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Simon N. Vandekar
- Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania
- Zaixu Cui
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Tyler M. Moore
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- David R. Roalf
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Kosha Ruparel
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Daniel H. Wolf
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Christos Davatzikos
- Department of Radiology, Perelman School of Medicine, University of Pennsylvania
- Ruben C. Gur
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Raquel E. Gur
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Russell T. Shinohara
- Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania
- Danielle S. Bassett
- Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania
- Theodore D. Satterthwaite
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-018-05317-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Co-morbidity and symptom overlap make it difficult to associate psychiatric disorders with unique neural signatures. Here, the authors use a data-driven approach to show that the symptom dimensions of mood, psychosis, fear and externalizing behavior exhibit unique patterns of functional dysconnectivity.
