Journal of Blood Medicine (Jan 2020)

Physical Activity and Thrombophilic Risk in a Short Series

  • Scudiero O,
  • Gentile L,
  • Ranieri A,
  • Coppola E,
  • Di Micco P,
  • Mazzaccara C,
  • D'alicandro G,
  • Leggiero E,
  • Frisso G,
  • Pastore L,
  • Lombardo B

Journal volume & issue
Vol. Volume 11
pp. 39 – 42

Abstract

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Olga Scudiero,1,2,* Luca Gentile,2,* Annaluisa Ranieri,1,2 Eduardo Coppola,3 Pierpaolo Di Micco,4 Cristina Mazzaccara,1,2 Giovanni D’alicandro,5 Eleonora Leggiero,2 Giulia Frisso,1,2 Lucio Pastore,1,2 Barbara Lombardo1,2 1Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, Napoli, Italia; 2CEINGE-Biotecnologie Avanzate, Napoli, Italia; 3Vulcanair S.p.A, Casoria, Italia; 4Dipartimento di Medicina Interna, Ospedale Fatebenefratelli, Napoli, Italia; 5Centro di Medicina dello Sport e delle Disabilità, Dipartimento di Neuroscienze e Riabilitazione, AORN, Santobono-Pausillipon, Napoli, Italia*These authors contributed equally to this workCorrespondence: Pierpaolo Di MiccoDipartimento di Medicina Interna, Ospedale Fatebenefratelli, Via Alessandro Manzoni, Napoli, NA 80123, ItaliaEmail [email protected] LombardoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, Corso Umberto I, 40, Napoli, NA 80138, ItaliaEmail [email protected]: The role of influence on protein C anticoagulant system and PC deficiency-related thrombophilic risk due to strenuous physical exercise is still under discussion. To investigate the modification of the protein C anticoagulant pathway after vigorous exercise, we measured ProC® Global assay, a protein C activity dependent clotting time, in 20 healthy subjects before and immediately after maximal treadmill exercise, and at 5, 15, 30 and 60 min in the recovery phase. The most evident change was a shortening of ProC® Global clotting time from the average basal value of 123 sec to 84 sec at 30 min in post-exercise. Our study shows that the coagulation unbalance observed after strenuous exercise and with no consequence in healthy individuals with normal PC level, could increase the thrombophilic risk in silent carriers of significant defects of the protein C system and occasionally trigger an episode of deep vein thrombosis.Keywords: ProC® Global, protein C unbalance after physical exercise, physical exercise; thrombophilic risk

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