Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity

• Alberto Mantovani,
• Marco Erreni,
• Paola Allavena,
• Diego Serrano,
• Miriam Redrado,
• Francisco Exposito,
• Alfonso Calvo,
• Clément Anfray,
• Francesco Mainini,
• Elisabeth Digifico,
• Akihiro Maeda,
• Marina Sironi,
• Achille Anselmo,
• Aldo Ummarino,
• Sara Gandoy,
• Marvin Martens,
• Susana Bravo,
• Fernando Torres Andón

Affiliations

Alberto Mantovani

IRCCS Humanitas Research Hospital, Rozzano, Italy

Marco Erreni

IRCCS Humanitas Research Hospital, Rozzano, Italy

Paola Allavena

IRCCS Humanitas Research Hospital, Rozzano, Italy

Diego Serrano

Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain

Miriam Redrado

Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain

Francisco Exposito

Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain

Alfonso Calvo

Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain

Clément Anfray

IRCCS Humanitas Research Hospital, Rozzano, Italy

Francesco Mainini

IRCCS Humanitas Research Hospital, Rozzano, Italy

Elisabeth Digifico

IRCCS Humanitas Research Hospital, Rozzano, Italy

Akihiro Maeda

IRCCS Humanitas Research Hospital, Rozzano, Italy

Marina Sironi

IRCCS Humanitas Research Hospital, Rozzano, Italy

Achille Anselmo

IRCCS Humanitas Research Hospital, Rozzano, Italy

Aldo Ummarino

IRCCS Humanitas Research Hospital, Rozzano, Italy

Sara Gandoy

Center for Research in Molecular Medicine and Chronic Diseases, Santiago de Compostela, Spain

Marvin Martens

Department of Bioinformatics, Maastricht University, Maastricht, Netherlands

Susana Bravo

Health Research Institute of Santigao de Compostela, Santiago de Compostela, Spain

Fernando Torres Andón

IRCCS Humanitas Research Hospital, Rozzano, Italy