Nature Communications (Jun 2020)

Genetic breakdown of a Tet-off conditional lethality system for insect population control

  • Yang Zhao,
  • Marc F. Schetelig,
  • Alfred M. Handler

DOI
https://doi.org/10.1038/s41467-020-16807-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Insect population control using conditional lethal systems could break down due to spontaneous mutations that render the system ineffective. Here the authors analyse the structure and frequency of such mutations in Drosophila and suggest the use of dual lethality systems to mitigate their survival.