Cancers (Sep 2023)
Comparing Robotic-Assisted to Open Radical Cystectomy in the Management of Non-Muscle-Invasive Bladder Cancer: A Propensity Score Matched-Pair Analysis
- Etienne Courboin,
- Romain Mathieu,
- Valentina Panetta,
- Georges Mjaess,
- Romain Diamand,
- Gregory Verhoest,
- Mathieu Roumiguié,
- Anne Sophie Bajeot,
- Francesco Soria,
- Chiara Lonati,
- Claudio Simeone,
- Giuseppe Simone,
- Umberto Anceschi,
- Paolo Umari,
- Ashwin Sridhar,
- John Kelly,
- Laura S. Mertens,
- Rafael Sanchez-Salas,
- Anna Colomer,
- Maria Angela Cerruto,
- Alessandro Antonelli,
- Wojciech Krajewski,
- Thierry Quackels,
- Alexandre Peltier,
- Francesco Montorsi,
- Alberto Briganti,
- Jeremy Y. C. Teoh,
- Benjamin Pradere,
- Marco Moschini,
- Thierry Roumeguère,
- Simone Albisinni
Affiliations
- Etienne Courboin
- Department of Urology, University Clinics of Brussels, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium
- Romain Mathieu
- Department of Urology, CHU Rennes, 35000 Rennes, France
- Valentina Panetta
- L’altrastatistica S.R.L., Consultancy & Training, Biostatistics Office, 00100 Rome, Italy
- Georges Mjaess
- Department of Urology, University Clinics of Brussels, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium
- Romain Diamand
- Department of Urology, Institut Jules Bordet, Université Libre de Bruxelles, 1070 Brussels, Belgium
- Gregory Verhoest
- Department of Urology, CHU Rennes, 35000 Rennes, France
- Mathieu Roumiguié
- Department of Urology, Andrology and Renal Transplantation, CHU Rangueil, Paul-Sabatier University, 31000 Toulouse, France
- Anne Sophie Bajeot
- Department of Urology, Andrology and Renal Transplantation, CHU Rangueil, Paul-Sabatier University, 31000 Toulouse, France
- Francesco Soria
- Division of Urology, Department of Surgical Sciences, San Giovanni Battista Hospital, University of Studies of Torino, 10024 Turin, Italy
- Chiara Lonati
- Department of Urology, Spedali Civili di Brescia, 25123 Brescia, Italy
- Claudio Simeone
- Department of Urology, Spedali Civili di Brescia, 25123 Brescia, Italy
- Giuseppe Simone
- Department of Urology, Regina Elena National Cancer Institute, 00100 Rome, Italy
- Umberto Anceschi
- Department of Urology, Regina Elena National Cancer Institute, 00100 Rome, Italy
- Paolo Umari
- Departement of Urology, Ospedale Maggiore della Caritá di Novara, Universitá del Piemonte Orientale, 28100 Novarra, Italy
- Ashwin Sridhar
- Division of Surgery and Interventional Sciences, University College London, London WC1E 6BT, UK
- John Kelly
- Division of Surgery and Interventional Sciences, University College London, London WC1E 6BT, UK
- Laura S. Mertens
- Department of Urology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
- Rafael Sanchez-Salas
- Department of Urology, Institut Mutualiste Montsouris, 70123 Paris, France
- Anna Colomer
- Department of Urology, Institut Mutualiste Montsouris, 70123 Paris, France
- Maria Angela Cerruto
- Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, 37100 Verona, Italy
- Alessandro Antonelli
- Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, 37100 Verona, Italy
- Wojciech Krajewski
- Department of Minimally Invasive and Robotic Urology, Wrocław Medical University, 50-556 Wroclaw, Poland
- Thierry Quackels
- Department of Urology, University Clinics of Brussels, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium
- Alexandre Peltier
- Department of Urology, Institut Jules Bordet, Université Libre de Bruxelles, 1070 Brussels, Belgium
- Francesco Montorsi
- Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
- Alberto Briganti
- Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
- Jeremy Y. C. Teoh
- S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
- Benjamin Pradere
- Department of Urology, University of Vienna, 1010 Vienna, Austria
- Marco Moschini
- Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
- Thierry Roumeguère
- Department of Urology, University Clinics of Brussels, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium
- Simone Albisinni
- Department of Urology, University Clinics of Brussels, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium
- DOI
- https://doi.org/10.3390/cancers15194732
- Journal volume & issue
-
Vol. 15,
no. 19
p. 4732
Abstract
Background: For non-muscle-invasive bladder cancer (NMIBC) requiring radical surgery, limited data are available comparing robotic-assisted radical cystectomy with intracorporeal urinary diversion (iRARC) to open radical cystectomy (ORC). The objective of this study was to compare the two surgical techniques. Methods: A multicentric cohort of 593 patients with NMIBC undergoing iRARC or ORC between 2015 and 2020 was prospectively gathered. Perioperative and pathologic outcomes were compared. Results: A total of 143 patients operated on via iRARC were matched to 143 ORC patients. Operative time was longer in the iRARC group (p = 0.034). Blood loss was higher in the ORC group (p p = 0.003). Length of stay was longer in the ORC group (p = 0.007). Post-operative complications did not differ significantly (all p > 0.05). DFS at 60 months was 55.9% in ORC and 75.2% in iRARC with a statistically significant difference (p = 0.033) found in the univariate analysis. Conclusion: We found that iRARC for patients with NMIBC is safe, associated with a lower blood loss, a lower transfusion rate and a shorter hospital stay compared to ORC. Complication rates were similar. No significant differences in survival analyses emerged across the two techniques.
Keywords
- cystectomy
- non-muscle-invasive bladder cancer
- robotic-assisted radical cystectomy
- open radical cystectomy
- intracorporeal urinary diversion
