TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis

Yuhan Xia; Kazuki Inoue; Yong Du; Stacey J. Baker; E. Premkumar Reddy; Matthew B. Greenblatt; Baohong Zhao

doi:10.1038/s41467-022-31475-1

Nature Communications (Jul 2022)

TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis

Yuhan Xia,
Kazuki Inoue,
Yong Du,
Stacey J. Baker,
E. Premkumar Reddy,
Matthew B. Greenblatt,
Baohong Zhao

Affiliations

Yuhan Xia: Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
Kazuki Inoue: Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
Yong Du: Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
Stacey J. Baker: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
E. Premkumar Reddy: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Matthew B. Greenblatt: Pathology and Laboratory Medicine, Weill Cornell Medical College
Baohong Zhao: Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery

DOI: https://doi.org/10.1038/s41467-022-31475-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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Mechanisms for inflammatory osteolysis are unclear. Here, Xia et al. find that TGFβ shifts the inflammatory action of TNF on macrophages to a potent osteoclastogenic function and identify a novel TGFβ/TNF-mediated non-canonical osteoclastogenic program.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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