Polyester‐tethered near‐infrared fluorophores confined in colloidal nanoparticles: Tunable and thermoresponsive aggregation and biomedical applications
Cangjie Yang,
Wei Zhang,
Xin Pang,
Fan Xiao,
Sandeep Kumar Kalva,
Yipeng Zhang,
Manojit Pramanik,
Leilei Tian,
Gang Liu,
Mingfeng Wang
Affiliations
Cangjie Yang
School of Chemical and Biomedical Engineering Nanyang Technological University Singapore Singapore
Wei Zhang
School of Science and Engineering The Chinese University of Hong Kong Shenzhen China
Xin Pang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen China
Fan Xiao
School of Materials Science and Engineering South University of Science and Technology Shenzhen China
Sandeep Kumar Kalva
School of Chemical and Biomedical Engineering Nanyang Technological University Singapore Singapore
Yipeng Zhang
School of Science and Engineering The Chinese University of Hong Kong Shenzhen China
Manojit Pramanik
School of Chemical and Biomedical Engineering Nanyang Technological University Singapore Singapore
Leilei Tian
School of Materials Science and Engineering South University of Science and Technology Shenzhen China
Gang Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen China
Mingfeng Wang
School of Chemical and Biomedical Engineering Nanyang Technological University Singapore Singapore
Abstract Intricate assembly of multiple molecular chromophores assisted by protein scaffolds is essential in tuning the optical absorption and energy transfer in the light‐harvesting complexes of the photosynthetic systems in nature. However, it remains a challenge to achieve such structural complexity and functionality in synthetic polymer‐chromophore systems. Here, we report a series of polyester‐tethered pyrrolopyrrole cyanine derivatives and their colloidal nanoparticles dispersed in water, which show tunable J‐ or H‐aggregation excitonic coupling and near‐infrared fluorescence by precise control of the polymer chain lengths, composition, and temperature. Moreover, the optimal fluorescence or photothermal effect of the J‐aggregate nanoparticles enables broad applications in fluorescence or photoacoustic bioimaging and phototherapy.
