Journal of Clinical Medicine (Aug 2019)
Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination
- Kazumasa Oda,
- Hideshi Okada,
- Akio Suzuki,
- Hiroyuki Tomita,
- Ryo Kobayashi,
- Kazuyuki Sumi,
- Kodai Suzuki,
- Chihiro Takada,
- Takuma Ishihara,
- Keiko Suzuki,
- Soichiro Kano,
- Kohei Kondo,
- Yuki Iwashita,
- Hirohisa Yano,
- Ryogen Zaikokuji,
- So Sampei,
- Tetsuya Fukuta,
- Yuichiro Kitagawa,
- Haruka Okamoto,
- Takatomo Watanabe,
- Tomonori Kawaguchi,
- Takao Kojima,
- Fumiko Deguchi,
- Nagisa Miyazaki,
- Noriaki Yamada,
- Tomoaki Doi,
- Takahiro Yoshida,
- Hiroaki Ushikoshi,
- Shozo Yoshida,
- Genzou Takemura,
- Shinji Ogura
Affiliations
- Kazumasa Oda
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Hideshi Okada
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Akio Suzuki
- Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan
- Hiroyuki Tomita
- Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Ryo Kobayashi
- Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan
- Kazuyuki Sumi
- Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan
- Kodai Suzuki
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Chihiro Takada
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Takuma Ishihara
- Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu 501-1194, Japan
- Keiko Suzuki
- Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan
- Soichiro Kano
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Kohei Kondo
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Yuki Iwashita
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Hirohisa Yano
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Ryogen Zaikokuji
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- So Sampei
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Tetsuya Fukuta
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Yuichiro Kitagawa
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Haruka Okamoto
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Takatomo Watanabe
- Department of Clinical Laboratory, Gifu University Hospital, Gifu 501-1194, Japan
- Tomonori Kawaguchi
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Takao Kojima
- Medical Health Check-up Center, Asahi University Hospital, Gifu 500-8523, Japan
- Fumiko Deguchi
- Medical Health Check-up Center, Asahi University Hospital, Gifu 500-8523, Japan
- Nagisa Miyazaki
- Department of Internal Medicine, Asahi University School of Dentistry, Mizuho 501-0223, Japan
- Noriaki Yamada
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Tomoaki Doi
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Takahiro Yoshida
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Hiroaki Ushikoshi
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Shozo Yoshida
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- Genzou Takemura
- Department of Internal Medicine, Asahi University School of Dentistry, Mizuho 501-0223, Japan
- Shinji Ogura
- Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
- DOI
- https://doi.org/10.3390/jcm8091320
- Journal volume & issue
-
Vol. 8,
no. 9
p. 1320
Abstract
Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (p = 0.016), aspartic aminotransferase concentration (AST, p = 0.020), blood urea nitrogen concentration (BUN, p = 0.013), triglyceride concentration (p < 0.001), and hematocrit (p = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration.
Keywords