CD30-positive cutaneous lymphoma: report of four cases with an emphasis on clinicopathological correlations

Abstract

Abstract: The classification of cutaneous lymphomas is multidisciplinary and requires the correlation between clinical, histopathological, immunohistochemical, and molecular diagnostic elements. In this article, we present four different cases of CD30-positive T-cell lymphoma with cutaneous manifestations. We compare cases with definitive diagnosis of papulosis lymphomatoid type C, primary cutaneous anaplastic large T-cell lymphoma, systemic anaplastic large T-cell lymphoma with secondary skin involvement, and mycosis fungoides with large cell transformation, highlighting the importance of clinicopathological correlation to classify these cases.

Keywords

• Anaplastic large cell lymphoma
• Cutaneous T-cell lymphoma
• Lymphomatoid papulosis
• Lymphoproliferative disorders
• Mycosis fungoides
• Primary cutaneous anaplastic large cell lymphoma