International Journal of General Medicine (Oct 2024)

A Predictive Model for Disseminated Intravascular Coagulopathy in Sepsis: An Observational Study

  • Fu Y,
  • He Y,
  • Zheng C,
  • Zeng J,
  • Ou H

Journal volume & issue
Vol. Volume 17
pp. 4845 – 4855

Abstract

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Yaojie Fu,1,* Yujing He,2,* Caixia Zheng,3 Jianyong Zeng,3 Hongjie Ou3 1Emergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People’s Republic of China; 2Intense Care Unit, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People’s Republic of China; 3Department of Infectious Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongjie Ou, Department of Infectious Diseases, The First Affiliated Hospital of Xiamen University, No. 10, Shanggu Road, Xiamen, Fujian, 361001, People’s Republic of China, Email [email protected] Yujing He, Intense Care Unit, The First Affiliated Hospital of Xiamen University, No. 10, Shanggu Road, Xiamen, Fujian, 361001, People’s Republic of China, Email [email protected]: Sepsis remains a significant global health challenge due to its high morbidity and mortality rates. Disseminated Intravascular Coagulopathy (DIC) represents a critical complication of sepsis, contributing to increased mortality and economic burden. Despite various prognostic scoring systems, there is a lack of a specific model for DIC prediction in sepsis patients.Methods: This observational study included 336 sepsis patients. Clinical and laboratory data were collected, and prognoses were defined according to established criteria.Results: We enrolled 336 patients, with 304 in the non-DIC group and 32 in the DIC group. Patients with DIC had notably lower platelet (PLT) and higher levels of prothrombin time (PT), lactate (LAC), and procalcitonin (PCT) compared to those without DIC. Univariate and multivariate analyses identified risk factors associated with the DIC, showing that PLT (OR = 0.985, 95% CI 0.978– 0.993, p − 2.12, the sensitivity for predicting DIC was 84.4%, and the specificity was 75.0%.Conclusion: Our study introduces a predictive model for DIC detection in sepsis patients, emphasizing the need for clinicians to focus on patients with high model scores for timely intervention.Keywords: sepsis, risk model, disseminated intravascular coagulopathy, platelet, mortality

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