Nature Communications (Feb 2018)

Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

  • Pierre Martinez,
  • Diego Mallo,
  • Thomas G. Paulson,
  • Xiaohong Li,
  • Carissa A. Sanchez,
  • Brian J. Reid,
  • Trevor A. Graham,
  • Mary K. Kuhner,
  • Carlo C. Maley

DOI
https://doi.org/10.1038/s41467-017-02621-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy genetic diversity.