Nature Communications (Sep 2022)

devCellPy is a machine learning-enabled pipeline for automated annotation of complex multilayered single-cell transcriptomic data

  • Francisco X. Galdos,
  • Sidra Xu,
  • William R. Goodyer,
  • Lauren Duan,
  • Yuhsin V. Huang,
  • Soah Lee,
  • Han Zhu,
  • Carissa Lee,
  • Nicholas Wei,
  • Daniel Lee,
  • Sean M. Wu

DOI
https://doi.org/10.1038/s41467-022-33045-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

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A major informatic challenge in single cell RNA-sequencing analysis is the precise annotation of datasets where cells exhibit complex multilayered identities or transitory states. Here the authors present devCellPy, a Python-based package that enables the automated prediction of cell types across complex cellular hierarchies, species, and experimental systems with high accuracy, particularly for developmental scRNA-seq datasets.