In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect
Henrik Gutte,
Adam E. Hansen,
Majbrit M.E. Larsen,
Sofie Rahbek,
Helle H. Johannesen,
Jan Ardenkjaer-Larsen,
Annemarie T. Kristensen,
Liselotte Højgaard,
Andreas Kjaer
Affiliations
Henrik Gutte
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Adam E. Hansen
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Majbrit M.E. Larsen
Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark
Sofie Rahbek
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Helle H. Johannesen
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Jan Ardenkjaer-Larsen
Department of Electrical Engineering, Technical University of Denmark, Lyngby 2800, Denmark
Annemarie T. Kristensen
Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark
Liselotte Højgaard
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Andreas Kjaer
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
In this communication the mismatch between simultaneous 18F-FDG-PET and a 13C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that 18F-FDG-PET may not always reflect the Warburg effect in all tumors.
