Nature Communications (Dec 2022)

Tumor fractions deciphered from circulating cell-free DNA methylation for cancer early diagnosis

  • Xiao Zhou,
  • Zhen Cheng,
  • Mingyu Dong,
  • Qi Liu,
  • Weiyang Yang,
  • Min Liu,
  • Junzhang Tian,
  • Weibin Cheng

DOI
https://doi.org/10.1038/s41467-022-35320-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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‘Circulating cell-free DNA can be used to predict cancer, but it is more challenging to assess in early stage cancer. Here, the authors created a diagnostic model using tumor fractions deciphered from circulating cfDNA methylation signatures, which exhibited an 86% sensitivity in detecting early-stage cancer.