Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Takumi Hirata; Yasumichi Arai; Shinsuke Yuasa; Yukiko Abe; Michiyo Takayama; Takashi Sasaki; Akira Kunitomi; Hiroki Inagaki; Motoyoshi Endo; Jun Morinaga; Kimio Yoshimura; Tetsuo Adachi; Yuichi Oike; Toru Takebayashi; Hideyuki Okano; Nobuyoshi Hirose

doi:10.1038/s41467-020-17636-0

Nature Communications (Jul 2020)

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Takumi Hirata,
Yasumichi Arai,
Shinsuke Yuasa,
Yukiko Abe,
Michiyo Takayama,
Takashi Sasaki,
Akira Kunitomi,
Hiroki Inagaki,
Motoyoshi Endo,
Jun Morinaga,
Kimio Yoshimura,
Tetsuo Adachi,
Yuichi Oike,
Toru Takebayashi,
Hideyuki Okano,
Nobuyoshi Hirose

Affiliations

Takumi Hirata: Centre for Supercentenarian Medical Research, Keio University School of Medicine
Yasumichi Arai: Centre for Supercentenarian Medical Research, Keio University School of Medicine
Shinsuke Yuasa: Department of Cardiology, Keio University School of Medicine
Yukiko Abe: Centre for Supercentenarian Medical Research, Keio University School of Medicine
Michiyo Takayama: Centre for Preventive Medicine, Keio University School of Medicine
Takashi Sasaki: Centre for Supercentenarian Medical Research, Keio University School of Medicine
Akira Kunitomi: Department of Cardiology, Keio University School of Medicine
Hiroki Inagaki: Tokyo Metropolitan Institute of Gerontology
Motoyoshi Endo: Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
Jun Morinaga: Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
Kimio Yoshimura: Department of Health Policy and Management, Keio University School of Medicine
Tetsuo Adachi: Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University
Yuichi Oike: Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University
Toru Takebayashi: Department of Preventive Medicine and Public Health, Keio University School of Medicine
Hideyuki Okano: Centre for Supercentenarian Medical Research, Keio University School of Medicine
Nobuyoshi Hirose: Centre for Supercentenarian Medical Research, Keio University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-17636-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

Read online

Supercentenarians are approaching the current longevity limit by avoiding or surviving major illness, thus identifying biomarkers for exceptional survival might provide insights into the protection against disease of aging. Here, the authors show low NT-proBNP and high albumin in plasma are the biological correlates of survival to the highest ages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal