Nature Communications (Mar 2017)
The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
- Silvia Grasso,
- Jennifer Chapelle,
- Vincenzo Salemme,
- Simona Aramu,
- Isabella Russo,
- Nicoletta Vitale,
- Ludovica Verdun di Cantogno,
- Katiuscia Dallaglio,
- Isabella Castellano,
- Augusto Amici,
- Giorgia Centonze,
- Nanaocha Sharma,
- Serena Lunardi,
- Sara Cabodi,
- Federica Cavallo,
- Alessia Lamolinara,
- Lorenzo Stramucci,
- Enrico Moiso,
- Paolo Provero,
- Adriana Albini,
- Anna Sapino,
- Johan Staaf,
- Pier Paolo Di Fiore,
- Giovanni Bertalot,
- Salvatore Pece,
- Daniela Tosoni,
- Stefano Confalonieri,
- Manuela Iezzi,
- Paola Di Stefano,
- Emilia Turco,
- Paola Defilippi
Affiliations
- Silvia Grasso
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Jennifer Chapelle
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Vincenzo Salemme
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Simona Aramu
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Isabella Russo
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Nicoletta Vitale
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Ludovica Verdun di Cantogno
- Candiolo Cancer Institute-FPO, IRCCS
- Katiuscia Dallaglio
- Research Infrastructure, IRCCS Arcispedale Santa Maria Nuova
- Isabella Castellano
- Candiolo Cancer Institute-FPO, IRCCS
- Augusto Amici
- Department of Bioscience and Veterinary Medicine, University of Camerino
- Giorgia Centonze
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Nanaocha Sharma
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Serena Lunardi
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Sara Cabodi
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Federica Cavallo
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Alessia Lamolinara
- Department of Medicine and Aging Science, Center of Excellence on Aging and Translational Medicine (CeSi-Met), G. D’Annunzio University
- Lorenzo Stramucci
- Department of Medicine and Aging Science, Center of Excellence on Aging and Translational Medicine (CeSi-Met), G. D’Annunzio University
- Enrico Moiso
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Paolo Provero
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Adriana Albini
- Scientific and Technology Pole, IRCCS MultiMedica
- Anna Sapino
- Candiolo Cancer Institute-FPO, IRCCS
- Johan Staaf
- Division of Oncology and Pathology, Department of Clinical Sciences, Lund University
- Pier Paolo Di Fiore
- Molecular Medicine Program, European Institute of Oncology
- Giovanni Bertalot
- Molecular Medicine Program, European Institute of Oncology
- Salvatore Pece
- Molecular Medicine Program, European Institute of Oncology
- Daniela Tosoni
- Molecular Medicine Program, European Institute of Oncology
- Stefano Confalonieri
- Molecular Medicine Program, European Institute of Oncology
- Manuela Iezzi
- Department of Medicine and Aging Science, Center of Excellence on Aging and Translational Medicine (CeSi-Met), G. D’Annunzio University
- Paola Di Stefano
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Emilia Turco
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- Paola Defilippi
- Department of Molecular Biotechnology and Health Sciences, University of Torino
- DOI
- https://doi.org/10.1038/ncomms14797
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
p140Cap adaptor proteins interfere with adhesion and growth factor-dependent signalling in cancer cells but the mechanisms are unclear. Here the authors show that p140Cap interferes with ERBB2-dependent activation of Rac GTPase-controlled circuitries reducing metastasis and cancer progression.
