Structure and mechanism of the human NHE1-CHP1 complex

Yanli Dong; Yiwei Gao; Alina Ilie; DuSik Kim; Annie Boucher; Bin Li; Xuejun C. Zhang; John Orlowski; Yan Zhao

doi:10.1038/s41467-021-23496-z

Nature Communications (Jun 2021)

Structure and mechanism of the human NHE1-CHP1 complex

Yanli Dong,
Yiwei Gao,
Alina Ilie,
DuSik Kim,
Annie Boucher,
Bin Li,
Xuejun C. Zhang,
John Orlowski,
Yan Zhao

Affiliations

Yanli Dong: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yiwei Gao: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Alina Ilie: Department of Physiology, McGill University
DuSik Kim: Department of Physiology, McGill University
Annie Boucher: Department of Physiology, McGill University
Bin Li: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Xuejun C. Zhang: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
John Orlowski: Department of Physiology, McGill University
Yan Zhao: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-23496-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Sodium/proton exchanger 1 (NHE1) and its obligate binding partner Calcineurin B-homologous protein 1 (CHP1) regulate intracellular pH and volume homeostasis. Structures of the human NHE1-CHP1 complex offer insight into the regulation of NHE1 pH-sensitivity by CHP1 and into the interactions with NHE1 inhibitors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal