Nature Communications (Aug 2020)

Genomic characterization of malignant progression in neoplastic pancreatic cysts

  • Michaël Noë,
  • Noushin Niknafs,
  • Catherine G. Fischer,
  • Wenzel M. Hackeng,
  • Violeta Beleva Guthrie,
  • Waki Hosoda,
  • Marija Debeljak,
  • Eniko Papp,
  • Vilmos Adleff,
  • James R. White,
  • Claudio Luchini,
  • Antonio Pea,
  • Aldo Scarpa,
  • Giovanni Butturini,
  • Giuseppe Zamboni,
  • Paola Castelli,
  • Seung-Mo Hong,
  • Shinichi Yachida,
  • Nobuyoshi Hiraoka,
  • Anthony J. Gill,
  • Jaswinder S. Samra,
  • G. Johan A. Offerhaus,
  • Anne Hoorens,
  • Joanne Verheij,
  • Casper Jansen,
  • N. Volkan Adsay,
  • Wei Jiang,
  • Jordan Winter,
  • Jorge Albores-Saavedra,
  • Benoit Terris,
  • Elizabeth D. Thompson,
  • Nicholas J. Roberts,
  • Ralph H. Hruban,
  • Rachel Karchin,
  • Robert B. Scharpf,
  • Lodewijk A. A. Brosens,
  • Victor E. Velculescu,
  • Laura D. Wood

DOI
https://doi.org/10.1038/s41467-020-17917-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.