Pan-immune-inflammation values in overweight and obese pregnant women with preeclampsia presenting with emergency hypertension

Abstract

BACKGROUND: Hypertensive disorders in pregnancy have been closely linked to the processes of platelet dysfunction and inflammation. This study aimed to explore the relationship between markers of inflammation and the severity of hypertension in women diagnosed with preeclampsia./ MATERIAL AND METHODS: This study was a prospective clinical trial that included overweight and obese women diagnosed with preeclampsia with severe features during the period between July 2024 and December 2024 in a university tertiary hospital. Admission data were assessed for clinical and laboratory findings and correlated to severity of hypertension. RESULTS: The study included 93 women with preeclampsia with severe features, with a mean age of 30.462 ± 6.1 years. Forty-seven (50.5%) women had emergency hypertension. Pan-immune-inflammation values (PIV) were significantly different between women with emergency and non-emergency hypertension, with a median (IQR) of 302.57 (182.53–530.38) and 440.85 (396.77–778.09), respectively (p < 0.001). Also, PIV was the only inflammatory marker that demonstrated a statistically significant positive correlation with systolic blood pressure (r = 0.225 and p = 0.030). CONCLUSION: A composite systemic inflammatory marker is a simple, noninvasive, widely available marker that could predict hypertensive emergencies in women with preeclampsia.

Keywords

• emergency hypertension
• inflammatory markers
• preeclampsia
• hospital stay