Nature Communications (Oct 2018)
Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
- Sarah E. Arthur,
- Aixiang Jiang,
- Bruno M. Grande,
- Miguel Alcaide,
- Razvan Cojocaru,
- Christopher K. Rushton,
- Anja Mottok,
- Laura K. Hilton,
- Prince Kumar Lat,
- Eric Y. Zhao,
- Luka Culibrk,
- Daisuke Ennishi,
- Selin Jessa,
- Lauren Chong,
- Nicole Thomas,
- Prasath Pararajalingam,
- Barbara Meissner,
- Merrill Boyle,
- Jordan Davidson,
- Kevin R. Bushell,
- Daniel Lai,
- Pedro Farinha,
- Graham W. Slack,
- Gregg B. Morin,
- Sohrab Shah,
- Dipankar Sen,
- Steven J. M. Jones,
- Andrew J. Mungall,
- Randy D. Gascoyne,
- Timothy E. Audas,
- Peter Unrau,
- Marco A. Marra,
- Joseph M. Connors,
- Christian Steidl,
- David W. Scott,
- Ryan D. Morin
Affiliations
- Sarah E. Arthur
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Aixiang Jiang
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Bruno M. Grande
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Miguel Alcaide
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Razvan Cojocaru
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Christopher K. Rushton
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Anja Mottok
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Laura K. Hilton
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Prince Kumar Lat
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Eric Y. Zhao
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Luka Culibrk
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Daisuke Ennishi
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Selin Jessa
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Lauren Chong
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Nicole Thomas
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Prasath Pararajalingam
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Barbara Meissner
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Merrill Boyle
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Jordan Davidson
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Kevin R. Bushell
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Daniel Lai
- Molecular Oncology, British Columbia Cancer Research Centre
- Pedro Farinha
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Graham W. Slack
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Gregg B. Morin
- Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency
- Sohrab Shah
- Molecular Oncology, British Columbia Cancer Research Centre
- Dipankar Sen
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Steven J. M. Jones
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Andrew J. Mungall
- Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency
- Randy D. Gascoyne
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Timothy E. Audas
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Peter Unrau
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Marco A. Marra
- Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency
- Joseph M. Connors
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Christian Steidl
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- David W. Scott
- Lymphoid Cancer Research, British Columbia Cancer Research Centre
- Ryan D. Morin
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- DOI
- https://doi.org/10.1038/s41467-018-06354-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
The driver mutations for the two main molecular subgroups of diffuse large B-cell lymphoma (DLBCL) are poorly defined. Here, an integrative genomics analysis identifies 3′ UTR NFKBIZ mutations within the activated B-cell DLBCL subgroup and small FCGR2B amplifications in the germinal centre B-cell DLBCL subgroup.
