Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores

Debasis Das; Huan Bao; Kevin C. Courtney; Lanxi Wu; Edwin R. Chapman

doi:10.1038/s41467-019-14072-7

Nature Communications (Jan 2020)

Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores

Debasis Das,
Huan Bao,
Kevin C. Courtney,
Lanxi Wu,
Edwin R. Chapman

Affiliations

Debasis Das: Department of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-Madison
Huan Bao: Department of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-Madison
Kevin C. Courtney: Department of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-Madison
Lanxi Wu: Department of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-Madison
Edwin R. Chapman: Department of Neuroscience and Howard Hughes Medical Institute, University of Wisconsin-Madison

DOI: https://doi.org/10.1038/s41467-019-14072-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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SNAREs mediate the formation of a fusion pore during exocytosis which connects the lumen of a vesicle with the extracellular space. Here, authors use single molecule approaches to define the role of synaptotagmin 1 and NSF in synaptic pore formation and dissolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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