Communications Biology (Jan 2021)
Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
- Takaaki Furihata,
- Shingo Takada,
- Naoya Kakutani,
- Satoshi Maekawa,
- Masaya Tsuda,
- Junichi Matsumoto,
- Wataru Mizushima,
- Arata Fukushima,
- Takashi Yokota,
- Nobuyuki Enzan,
- Shouji Matsushima,
- Haruka Handa,
- Yoshizuki Fumoto,
- Junko Nio-Kobayashi,
- Toshihiko Iwanaga,
- Shinya Tanaka,
- Hiroyuki Tsutsui,
- Hisataka Sabe,
- Shintaro Kinugawa
Affiliations
- Takaaki Furihata
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Shingo Takada
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Naoya Kakutani
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Satoshi Maekawa
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Masaya Tsuda
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Junichi Matsumoto
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Wataru Mizushima
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Arata Fukushima
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Takashi Yokota
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Nobuyuki Enzan
- Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
- Shouji Matsushima
- Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
- Haruka Handa
- Department of Molecular Biology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Yoshizuki Fumoto
- Department of Molecular Biology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Junko Nio-Kobayashi
- Laboratory of Histology and Cytology, Department of Anatomy, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Toshihiko Iwanaga
- Laboratory of Histology and Cytology, Department of Anatomy, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Shinya Tanaka
- Department of Cancer Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Hiroyuki Tsutsui
- Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences
- Hisataka Sabe
- Department of Molecular Biology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Shintaro Kinugawa
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- DOI
- https://doi.org/10.1038/s42003-021-01675-4
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 11
Abstract
Takaaki Furihata et al. report a new mouse model with heart-specific deletion of the mitochondrial protein, mitoNEET. Their results suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.
