A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

Stefan Klein-Hessling; Ronald Rudolf; Khalid Muhammad; Klaus-Peter Knobeloch; Muhammad Ahmad Maqbool; Pierre Cauchy; Jean-Christophe Andrau; Andris Avots; Claudio Talora; Volker Ellenrieder; Isabella Screpanti; Edgar Serfling; Amiya Kumar Patra

doi:10.1038/ncomms11841

Nature Communications (Jun 2016)

A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

Stefan Klein-Hessling,
Ronald Rudolf,
Khalid Muhammad,
Klaus-Peter Knobeloch,
Muhammad Ahmad Maqbool,
Pierre Cauchy,
Jean-Christophe Andrau,
Andris Avots,
Claudio Talora,
Volker Ellenrieder,
Isabella Screpanti,
Edgar Serfling,
Amiya Kumar Patra

Affiliations

Stefan Klein-Hessling: Department of Molecular Pathology, Institute for Pathology, University of Wuerzburg
Ronald Rudolf: Department of Molecular Pathology, Institute for Pathology, University of Wuerzburg
Khalid Muhammad: Department of Molecular Pathology, Institute for Pathology, University of Wuerzburg
Klaus-Peter Knobeloch: Department of Pathology, Institute of Neuropathology, University Clinic Freiburg
Muhammad Ahmad Maqbool: Institute de Génétique Moléculaire de Montpellier (IGMM)
Pierre Cauchy: Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham
Jean-Christophe Andrau: Institute de Génétique Moléculaire de Montpellier (IGMM)
Andris Avots: Department of Molecular Pathology, Institute for Pathology, University of Wuerzburg
Claudio Talora: Department of Molecular Medicine, Laboratory of Molecular Pathology, Sapienza University of Rome
Volker Ellenrieder: Department of Gastroenterology II, University of Goettingen
Isabella Screpanti: Department of Molecular Medicine, Laboratory of Molecular Pathology, Sapienza University of Rome
Edgar Serfling: Department of Molecular Pathology, Institute for Pathology, University of Wuerzburg
Amiya Kumar Patra: Department of Molecular Pathology, Institute for Pathology, University of Wuerzburg

DOI: https://doi.org/10.1038/ncomms11841
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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