Nature Communications (Dec 2018)
Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
- Kuo Zhang,
- Yuying Zhang,
- Lijie Gu,
- Miaomiao Lan,
- Chuncheng Liu,
- Meng Wang,
- Yang Su,
- Mengxu Ge,
- Tongtong Wang,
- Yingying Yu,
- Chang Liu,
- Lei Li,
- Qiuyan Li,
- Yaofeng Zhao,
- Zhengquan Yu,
- Fudi Wang,
- Ning Li,
- Qingyong Meng
Affiliations
- Kuo Zhang
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Yuying Zhang
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Lijie Gu
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Miaomiao Lan
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Chuncheng Liu
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Meng Wang
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Yang Su
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Mengxu Ge
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Tongtong Wang
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Yingying Yu
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Chang Liu
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Lei Li
- Qiuyan Li
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Yaofeng Zhao
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Zhengquan Yu
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Fudi Wang
- Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University
- Ning Li
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- Qingyong Meng
- State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-018-07638-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
“Satellite cells are crucial for skeletal muscle regeneration. Here the authors show that immunoglobulin superfamily containing leucine-rich repeat (Islr) promotes skeletal muscle regeneration via a mechanism involving Dishevelled-2 stabilization in satellite cells and protection from autophagy.
