Acta Medica Medianae (Dec 2004)

HUMAN GLOMERULAR VOLUME QUANTIFICATIONDURING THE AGING PROCESS

  • Dejan Zdravković,
  • Snežana Pavlović,
  • Sladjana Ugrenović,
  • Rade Čukuranović,
  • Ivan Jovanović,
  • Vesna Stojanović,
  • Natalija Stefanović

Journal volume & issue
Vol. 43, no. 4
pp. 5 – 7

Abstract

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Kidney function is directly related to the changes of renal tissue, especially glomeruli, which is particularly distinct during the aging process. The impossibility of kidney function substitution points to the need for glomerular morphologic and functional characteristics estimation during the aging process.Human cadaveric kidney tissue samples were used as material during research. Age of cadavers ranged from 20 to 70 years and they were classified according to the scheme: I (20–29); II (30–39); III (40–49); IV (50–59); V (60–69) i VI (older than 70). After the routine histologic preparation of the renal tissue the slices were analized stereologicaly under the light microscope with projection screen (Reichert Visopan) with 40 x lens magnification. M42 test system was used and 100, by unbased method selected glomeruli, were analyzed.Average glomerular capillary network volume shows significant increase (p< 0,001) as far as to the age of 50 years in regard to the age of 20 to 29 years. This parameter shows insignificant decrease after the age of 50 until the age of 70 years. This decrease was significant after the age of 70 years in regard to the period of the 20 to 29 (p< 0,05) and the period of 40 to 49 years (p<0,01).

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