Nature Communications (Jan 2019)
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
- Lei Xiong,
- Feng Wu,
- Qiong Wu,
- Liangliang Xu,
- Otto K. Cheung,
- Wei Kang,
- Myth T. Mok,
- Lemuel L. M. Szeto,
- Cheuk-Yin Lun,
- Raymond W. Lung,
- Jinglin Zhang,
- Ken H. Yu,
- Sau-Dan Lee,
- Guangcun Huang,
- Chiou-Miin Wang,
- Joseph Liu,
- Zhuo Yu,
- Dae-Yeul Yu,
- Jian-Liang Chou,
- Wan-Hong Huang,
- Bo Feng,
- Yue-Sun Cheung,
- Paul B. Lai,
- Patrick Tan,
- Nathalie Wong,
- Michael W. Chan,
- Tim H. Huang,
- Kevin Y. Yip,
- Alfred S. Cheng,
- Ka-Fai To
Affiliations
- Lei Xiong
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Feng Wu
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Qiong Wu
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Liangliang Xu
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Otto K. Cheung
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Wei Kang
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Myth T. Mok
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Lemuel L. M. Szeto
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Cheuk-Yin Lun
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Raymond W. Lung
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Jinglin Zhang
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Ken H. Yu
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Sau-Dan Lee
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Guangcun Huang
- Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio
- Chiou-Miin Wang
- Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio
- Joseph Liu
- Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio
- Zhuo Yu
- Department of Liver Disease, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
- Dae-Yeul Yu
- Disease Model Research Laboratory, Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology
- Jian-Liang Chou
- Department of Biomedical Sciences, National Chung Cheng University
- Wan-Hong Huang
- Department of Biomedical Sciences, National Chung Cheng University
- Bo Feng
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Yue-Sun Cheung
- Department of Surgery, The Chinese University of Hong Kong
- Paul B. Lai
- Department of Surgery, The Chinese University of Hong Kong
- Patrick Tan
- Program in Cancer and Stem Cell Biology, Duke-NUS Medical School
- Nathalie Wong
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Michael W. Chan
- Department of Biomedical Sciences, National Chung Cheng University
- Tim H. Huang
- Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio
- Kevin Y. Yip
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Alfred S. Cheng
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Ka-Fai To
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-018-08245-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.
