Acute Fatal Hemorrhage-Induced Activation of Lipid Peroxidation Processes and Cardiac Lesion

Abstract

The time course of changes in myocardial lipid peroxidation processes was studied in an experiment on albino male rats that had experienced 4-minute clinical death. There was an alternation of periods of a significant increase (minute 90, hours 3—6, and days 1—3 and 14) and a decrease (days 7, 21, and 30) in the rate of lipoprotein processes and corresponding changes in the content of lipid hydroperoxides and Schiff s bases. Activation of lipid peroxidation processes occurred with deficiency of bioantioxidants and with inhibition of enzymes that made antiradical and antiperoxide protection of cardiomyocytes.acute fatal hemorrhage; resuscitation; heart; lipid peroxidation

Keywords

• acute fatal hemorrhage
• resuscitation
• heart
• lipid peroxidation