Modulation of Siglec‑7 Signaling Via In Situ-Created High-Affinity cis-Ligands

• Senlian Hong,
• Chenhua Yu,
• Emily Rodrigues,
• Yujie Shi,
• Hongmin Chen,
• Peng Wang,
• Digantkumar G. Chapla,
• Tao Gao,
• Ruoxuan Zhuang,
• Kelley W. Moremen,
• James C. Paulson,
• Matthew S. Macauley,
• Peng Wu

Affiliations

Senlian Hong

†State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China

Chenhua Yu

∥Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States

Emily Rodrigues

∇Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Yujie Shi

∥Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States

Hongmin Chen

§Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, China

Peng Wang

⊥Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States

Digantkumar G. Chapla

Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States

Tao Gao

§Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, China

Ruoxuan Zhuang

§Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, China

Kelley W. Moremen

Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States

James C. Paulson

∥Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States

Matthew S. Macauley

∇Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

Peng Wu

∥Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States