Медицинская иммунология (Jul 2014)

CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS

  • A. V. Sosnina,
  • A. I. Autenshlyus,
  • N. V. Velikaya,
  • N. A. Varaksin,
  • M. Yu. Rukhavishnikov,
  • E. S. Mikhailova,
  • D. V. Morozov,
  • S. A. Fursov,
  • N. V. Agarina

DOI
https://doi.org/10.15789/1563-0625-2011-2-3-197-204
Journal volume & issue
Vol. 13, no. 2-3
pp. 197 – 204

Abstract

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Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204

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