Expression of ERα, ERβ and Co-Regulator PELP1/MNAR in Colorectal Cancer: Prognostic Significance and Clinicopathologic Correlations

Petros D. Grivas; Vassiliki Tzelepi; Georgia Sotiropoulou-Bonikou; Zinovia Kefalopoulou; Athanasios G. Papavassiliou; Haralabos Kalofonos

doi:10.3233/CLO-2009-0467

Cellular Oncology (Jan 2009)

Expression of ERα, ERβ and Co-Regulator PELP1/MNAR in Colorectal Cancer: Prognostic Significance and Clinicopathologic Correlations

Petros D. Grivas,
Vassiliki Tzelepi,
Georgia Sotiropoulou-Bonikou,
Zinovia Kefalopoulou,
Athanasios G. Papavassiliou,
Haralabos Kalofonos

Affiliations

Petros D. Grivas: Division of Oncology and Clinical Oncology Laboratory, Medical School, University of Patras, Patras, Greece
Vassiliki Tzelepi: Department of Anatomy and Histology–Embryology, Medical School, University of Patras, Patras, Greece
Georgia Sotiropoulou-Bonikou: Department of Anatomy and Histology–Embryology, Medical School, University of Patras, Patras, Greece
Zinovia Kefalopoulou: Department of Anatomy and Histology–Embryology, Medical School, University of Patras, Patras, Greece
Athanasios G. Papavassiliou: Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece
Haralabos Kalofonos: Division of Oncology and Clinical Oncology Laboratory, Medical School, University of Patras, Patras, Greece

DOI: https://doi.org/10.3233/CLO-2009-0467
Journal volume & issue: Vol. 31, no. 3
pp. 235 – 247

Abstract

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Background: Estrogen receptor β (ERβ) is abundantly expressed in colorectal tissue, but its role in colorectal carcinogenesis remains elusive. ER novel co-regulator, proline-, glutamic acid- and leucine-rich protein 1 (PELP1/MNAR) has been characterized, but its expression in colorectal carcinomas has not been investigated.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://www.hindawi.com/journals/acp/

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