Research of free radical and tissue energy supply processes on rats subjected to concurrent Tetrachlormethane and Adrenaline impact after Mexidol administration

Abstract

Aleksevych K. O., Fira L. S., Hrymalyuk O. I., Shtroblya A. L. Research of free radical and tissue energy supply processes on rats subjected to concurrent Tetrachlormethane and Adrenaline impact after Mexidol administration. Journal of Education, Health and Sport. 2015;5(3):269-278. ISSN 2391-8306. DOI: 10.5281/zenodo.16439 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%283%29%3A269-278 https://pbn.nauka.gov.pl/works/550559 http://dx.doi.org/10.5281/zenodo.16439 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.01.2014. Revised 27.02.2015. Accepted: 12.03.2015. UDC 599.32+615.9.]-092.4 RESEARCH OF FREE RADICAL AND TISSUE ENERGY SUPPLY PROCESSES ON RATS SUBJECTED TO CONCURRENT TETRACHLORMETHANE AND ADRENALINE IMPACT AFTER MEXIDOL ADMINISTRATION Aleksevych K. O.1, Fira L. S.1, Hrymalyuk O. I.1, Shtroblya A. L.2 1State Higher Educational Institution I.Ya. Horbachevsky Ternopil State Medical University, Ministry of Public Health, Ukraine 2State Higher Educational Institution Yzhhorod National University, Ukraine Summary Experiments on rats subjected to simultaneous impact of tetrachlormethane and increased adrenaline doses, revealed activated protein oxidative modification and lipoperoxidation. This caused suppression of tissue energy supply that is confirmed by decreased cytochrome oxidase and succinate dehydrogenase. The detected disorders were found to induce cardiocyte cytolysis, indicated by increased blood serum kreatine phosphokinase and lactate dehydrogenase activity alongside with its decrease in rats’ myocardium after the impact. Mexidol, used as an antioxidant, revealed positive influence on free radical oxidation processes as well as on the normalization of myocardial bioenergetics. Key words: tetrachlormethane, adrenaline, protein oxidative modification, lipoperoxidation, energy supply, Mexidol.

Keywords

• tetrachlormethane, adrenaline, protein oxidative modification, lipoperoxidation, energy supply, mexidol