Nature Communications (Feb 2016)

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis

  • Qingwen Xu,
  • Yuxia Zhang,
  • Qing Wei,
  • Yan Huang,
  • Jinghua Hu,
  • Kun Ling

DOI
https://doi.org/10.1038/ncomms10777
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the initiation of ciliogenesis.