Clinics (Dec 2012)

Mechanical thrombectomy with solitaire stent retrieval for acute ischemic stroke in a Brazilian population

  • Luis Henrique de Castro-Afonso,
  • Thiago Giansante Abud,
  • Octávio Marques Pontes-Neto,
  • Lucas Moretti Monsignore,
  • Guilherme Seizem Nakiri,
  • Pedro Telles Cougo-Pinto,
  • Lívia de Oliveira,
  • Daniela dos Santos,
  • Francisco A Dias,
  • Soraia Cabette Ramos Fábio,
  • Francisco Antônio Coletto,
  • Daniel Giansante Abud

DOI
https://doi.org/10.6061/clinics/2012(12)06
Journal volume & issue
Vol. 67, no. 12
pp. 1379 – 1386

Abstract

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OBJECTIVE: Large vessel occlusion in acute ischemic stroke is associated with low recanalization rates under intravenous thrombolysis. We evaluated the safety and efficacy of the Solitaire AB stent in treating acute ischemic stroke. METHODS: Patients presenting with acute ischemic stroke were prospectively evaluated. The neurological outcomes were assessed using the National Institutes of Health Stroke Scale and the modified Rankin Scale. Time was recorded from the symptom onset to the recanalization and procedure time. Recanalization was assessed using the thrombolysis in cerebral infarction score. RESULTS: Twenty-one patients were evaluated. The mean patient age was 65, and the National Institutes of Health Stroke Scale scores ranged from 7 to 28 (average 17±6.36) at presentation. The vessel occlusions occurred in the middle cerebral artery (61.9%), distal internal carotid artery (14.3%), tandem carotid occlusion (14.3%), and basilarartery (9.5%). Primary thrombectomy, rescue treatment and a bridging approach represented 66.6%, 28.6%, and 4.8% of the performed procedures, respectively. The mean time from symptom onset to recanalization was 356.5±107.8 minutes (range, 80-586 minutes). The mean procedure time was 60.4±58.8 minutes (range, 14-240 minutes). The overall recanalization rate (thrombolysis in cerebral infarction scores of 3 or 2b) was 90.4%, and the symptomatic intracranial hemorrhage rate was 14.2%. The National Institutes of Health Stroke Scale scores at discharge ranged from 0 to 25 (average 6.9±7). At three months, 61.9% of the patients had a modified Rankin Scale score of 0 to 2, with an overall mortality rate of 9.5%. CONCLUSIONS: Intra-arterial thrombectomy with the Solitaire AB device appears to be safe and effective. Large randomized trials are necessary to confirm the benefits of this approach in acute ischemic stroke.

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