Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro

• Chia-Ju Hsieh,
• Kuiying Xu,
• Iljung Lee,
• Thomas J. A. Graham,
• Zhude Tu,
• Dhruva Dhavale,
• Paul Kotzbauer,
• Robert H. Mach

Affiliations

Chia-Ju Hsieh

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States

Kuiying Xu

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States

Iljung Lee

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States

Thomas J. A. Graham

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States

Zhude Tu

‡Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States

Dhruva Dhavale

§Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States

Paul Kotzbauer

§Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States

Robert H. Mach

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States