195 Overcoming the dose-response prediction limitation from bench to clinic for T-cell engagers: using quantitative systems pharmacology (QSP) modelling in the development of CDR404 for solid tumors

• Fei Hua,
• Swethajit Biswas,
• Melissa Vrohlings,
• Stephanie Jungmichel,
• Ivana Tosevski,
• Nadia Sanchez,
• Leonardo Borras,
• Drew Marquis,
• Scott Gruver

Affiliations

Fei Hua

2Applied BioMath, LLC, Concord, MA, USA

Swethajit Biswas

5CDR-Life, Zurich, Switzerland

Melissa Vrohlings

1CDR-Life, Schlieren, Switzerland

Stephanie Jungmichel

3CDR-Life, Schlieren/Zurich, Zurich, Switzerland

Ivana Tosevski

4CDR-Life, Horgen, Zurich, Switzerland

Nadia Sanchez

4CDR-Life, Horgen, Zurich, Switzerland

Leonardo Borras

4CDR-Life, Horgen, Zurich, Switzerland

Drew Marquis

2Applied BioMath, LLC, Concord, MA, USA

Scott Gruver

2Applied BioMath, LLC, Concord, MA, USA