Nature Communications (May 2020)
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
- Samuel M. Gonçalves,
- Cláudio Duarte-Oliveira,
- Cláudia F. Campos,
- Vishukumar Aimanianda,
- Rob ter Horst,
- Luis Leite,
- Toine Mercier,
- Paulo Pereira,
- Miguel Fernández-García,
- Daniela Antunes,
- Cláudia S. Rodrigues,
- Catarina Barbosa-Matos,
- Joana Gaifem,
- Inês Mesquita,
- António Marques,
- Nuno S. Osório,
- Egídio Torrado,
- Fernando Rodrigues,
- Sandra Costa,
- Leo AB. Joosten,
- Katrien Lagrou,
- Johan Maertens,
- João F. Lacerda,
- António Campos,
- Gordon D. Brown,
- Axel A. Brakhage,
- Coral Barbas,
- Ricardo Silvestre,
- Frank L. van de Veerdonk,
- Georgios Chamilos,
- Mihai G. Netea,
- Jean-Paul Latgé,
- Cristina Cunha,
- Agostinho Carvalho
Affiliations
- Samuel M. Gonçalves
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Cláudio Duarte-Oliveira
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Cláudia F. Campos
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Vishukumar Aimanianda
- Unité des Aspergillus, Institut Pasteur
- Rob ter Horst
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre
- Luis Leite
- STMO, Instituto Português de Oncologia
- Toine Mercier
- Department of Hematology, UZ Leuven
- Paulo Pereira
- Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa
- Miguel Fernández-García
- Center for Metabolomics and Bioanalysis, Faculty of Pharmacy, San Pablo CEU University
- Daniela Antunes
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Cláudia S. Rodrigues
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Catarina Barbosa-Matos
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Joana Gaifem
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Inês Mesquita
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- António Marques
- Serviço de Imuno-Hemoterapia, Hospital de Braga
- Nuno S. Osório
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Egídio Torrado
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Fernando Rodrigues
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Sandra Costa
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Leo AB. Joosten
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre
- Katrien Lagrou
- Department of Microbiology and Immunology, KU Leuven
- Johan Maertens
- Department of Hematology, UZ Leuven
- João F. Lacerda
- Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa
- António Campos
- STMO, Instituto Português de Oncologia
- Gordon D. Brown
- MRC Centre for Medical Mycology, University of Aberdeen
- Axel A. Brakhage
- Department of Molecular and Applied Microbiology, Leibniz-Institute for Natural Product Research and Infection Biology
- Coral Barbas
- Center for Metabolomics and Bioanalysis, Faculty of Pharmacy, San Pablo CEU University
- Ricardo Silvestre
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Frank L. van de Veerdonk
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre
- Georgios Chamilos
- School of Medicine, University of Crete
- Mihai G. Netea
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Centre
- Jean-Paul Latgé
- Unité des Aspergillus, Institut Pasteur
- Cristina Cunha
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Agostinho Carvalho
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- DOI
- https://doi.org/10.1038/s41467-020-16120-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Macrophages undergo a Warburg-like switch from oxidative phosphorylation to glycolysis in response to inflammatory stimulus. Here the authors show that fungal melanin can trigger this switch in human macrophages by sequestering calcium in the phagosome and enabling protection against Aspergillus fumigatus infection.
