Biodegradable Nickel Disulfide Nanozymes with GSH-Depleting Function for High-Efficiency Photothermal-Catalytic Antibacterial Therapy
Xianwen Wang,
Linxin Fan,
Liang Cheng,
Yanbin Sun,
Xiyu Wang,
Xiaoyan Zhong,
Qianqian Shi,
Fei Gong,
Yu Yang,
Yan Ma,
Zhaohua Miao,
Zhengbao Zha
Affiliations
Xianwen Wang
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, P. R. China
Linxin Fan
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China
Liang Cheng
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, P. R. China; Corresponding author
Yanbin Sun
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China
Xiyu Wang
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, P. R. China
Xiaoyan Zhong
National Engineering Research Centre for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China
Qianqian Shi
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China
Fei Gong
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, P. R. China
Yu Yang
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, P. R. China
Yan Ma
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China
Zhaohua Miao
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China
Zhengbao Zha
School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China; Corresponding author
Summary: Bacterial infections caused by pathogens have always been a thorny issue that threatens human health, and there is urgent need to develop a new generation of antimicrobial nano-agents and treatments. Herein, biodegradable nickel disulfide (ND) nanozymes as excellent antibacterial agents that integrate excellent photothermal performance, nano-catalysis property, and glutathione (GSH)-depleting function have been successfully constructed. The ND nanozymes can effectively catalyze the decomposition of H2O2 to produce ⋅OH, and the hyperthermia of ND nanozymes generated by photothermal therapy (PTT) can further increase its catalytic activity, which provides rapid and effective bacterial killing effect compared with nano-catalytic treatment or PTT alone. Surprisingly, the ND nanozymes have the ability of GSH consumption, thus enhancing its sterilization effect. Moreover, the ND nanozymes are biodegradable nanomaterials that do not cause any significant toxicity in vivo. Collectively, the ND nanozymes with excellent photothermal performance, catalytic activity, and GSH-depleting function are used for high-efficiency sterilization.
