Journal of Inflammation Research (Mar 2023)
Metabolic Reprogramming and Its Regulatory Mechanism in Sepsis-Mediated Inflammation
Abstract
Wenzhang Liu,1,* Tianyi Liu,1,* Yongjun Zheng,1 Zhaofan Xia1,2 1Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China; 2Research Unit of Key Techniques for Treatment of burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongjun Zheng; Zhaofan Xia, Email [email protected]; [email protected]: Sepsis is a systemic inflammatory disease caused by an infection that can lead to multiple organ failure. Sepsis alters energy metabolism, leading to metabolic reprogramming of immune cells, which consequently disrupts innate and adaptive immune responses, triggering hyperinflammation and immunosuppression. This review summarizes metabolic reprogramming and its regulatory mechanism in sepsis-induced hyperinflammation and immunosuppression, highlights the significance and intricacies of immune cell metabolic reprogramming, and emphasizes the pivotal role of mitochondria in metabolic regulation and treatment of sepsis. This review provides an up-to-date overview of the relevant literature to inform future research directions in understanding the regulation of sepsis immunometabolism. Metabolic reprogramming has great promise as a new target for sepsis treatment in the future.Keywords: immune cell, hyperinflammation, immunosuppression, immunometabolism, mitochondria
