A Translation-Aborting Small Open Reading Frame in the Intergenic Region Promotes Translation of a Mg
2+
Transporter in
Salmonella
Typhimurium

Eunna Choi; Yoontak Han; Shinae Park; Hyojeong Koo; Jung-Shin Lee; Eun-Jin Lee

doi:10.1128/mBio.03376-20

mBio (Apr 2021)

A Translation-Aborting Small Open Reading Frame in the Intergenic Region Promotes Translation of a Mg 2+ Transporter in Salmonella Typhimurium

Eunna Choi,
Yoontak Han,
Shinae Park,
Hyojeong Koo,
Jung-Shin Lee,
Eun-Jin Lee

Affiliations

Eunna Choi: Department of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
Yoontak Han: Department of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
Shinae Park: Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea
Hyojeong Koo: Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea
Jung-Shin Lee: Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea
Eun-Jin Lee: ORCiD; Department of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea

DOI: https://doi.org/10.1128/mBio.03376-20
Journal volume & issue: Vol. 12, no. 2

Abstract

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Translation initiation regions in mRNAs that include the ribosome-binding site (RBS) and the start codon are often sequestered within a secondary structure. Therefore, to initiate protein synthesis, the mRNA secondary structure must be unfolded to allow the RBS to be accessible to the ribosome.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal