Nature Communications (Jan 2019)

A miniature multi-contrast microscope for functional imaging in freely behaving animals

  • Janaka Senarathna,
  • Hang Yu,
  • Callie Deng,
  • Alice L. Zou,
  • John B. Issa,
  • Darian H. Hadjiabadi,
  • Stacy Gil,
  • Qihong Wang,
  • Betty M. Tyler,
  • Nitish V. Thakor,
  • Arvind P. Pathak

DOI
https://doi.org/10.1038/s41467-018-07926-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Measuring multiple neurophysiologic variables usually requires bulky benchtop optical systems and working with anesthetized animals. Here the authors present a miniature portable microscope for neurovascular imaging in awake rodents, combining fluorescence, intrinsic optical signals and laser speckle contrast.