Exploring the association between childhood trauma and limbic system subregion volumes in healthy individuals: a neuroimaging study

Abstract

Abstract Background Childhood trauma (CT) is a major risk factor for psychiatric disorders. Emotional and cognitive functions are often affected in many psychiatric conditions, and these functions are mediated by the limbic system. However, previous research has primarily focused on patient populations. Therefore, we aim to examine the impact of CT on the limbic brain structure in healthy individuals. Methods We enrolled 48 individuals in health, evenly split into two groups: 24 healthy participants with CT (HP-CT) and 24 healthy participants without CT (HP-nCT). They underwent scale assessments and MRI data acquisition. Comparisons between the two groups were performed after subcortical subregion volume segmentation using FreeSufer. Lastly, we examined correlations between volume changes and scale scores. Results We found that HP-CT group had smaller volumes in several subregions of the hippocampus, amygdala, and cortical limbic structures, including the subiculum (Sub) head and body, cornu ammonis (CA)1 head, molecular layer (ML) head, granule cell layer of the dentate gyrus (GC-ML-DG) body, CA4 body, fimbria, hippocampus-amygdala transition area (HATA), whole hippocampus head and body, whole hippocampus, basal nucleus (Ba), accessory basal nucleus (AB), cortico-amygdaloid transition area (CAT), paralaminar nucleus (PL) of the left hemisphere; and hippocampal tail, presubiculum (PreSub) body, and basal forebrain of the right hemisphere. Volume changes in the CA4 body and GC-ML-DG body were correlated with sexual abuse. Changes in the volume of the right basal forebrain were linked to emotional neglect. However, these findings were not significant after correction for multiple comparisons. Conclusion CT impacts multiple structures of the limbic system, including the hippocampus, and amygdala. This also suggests that region-specific changes within the limbic system can serve as clinical biomarkers supporting cross-diagnostic psychiatric illnesses.

Keywords

• Healthy individual
• Childhood trauma
• Limbic system
• Subregions
• Volume
• Brain imaging