Nature Communications (Feb 2023)

Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys

  • Quentin Le Hingrat,
  • Paola Sette,
  • Cuiling Xu,
  • Andrew R. Rahmberg,
  • Lilas Tarnus,
  • Haritha Annapureddy,
  • Adam Kleinman,
  • Egidio Brocca-Cofano,
  • Ranjit Sivanandham,
  • Sindhuja Sivanandham,
  • Tianyu He,
  • Daniel J. Capreri,
  • Dongzhu Ma,
  • Jacob D. Estes,
  • Jason M. Brenchley,
  • Cristian Apetrei,
  • Ivona Pandrea

DOI
https://doi.org/10.1038/s41467-023-36379-2
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 17

Abstract

Read online

HIV infection results in the depletion of CD4+ T cells overtime and the loss of coordinated cellular immunity, but how this corresponds to the SIV infected African Green Monkey (AGM) model of non-progressive disease is not known. Here the authors assess the impact of experimental CD4+ T cell depletion in AGM and show that lack of disease progression and resistance to AIDS in this model are independent of CD4+ T cell loss.