Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue

Erin J. Stephenson; Amanda S. Stayton; Aarti Sethuraman; Prahlad K. Rao; Alice Meyer; Charles Klazer Gomes; Molly C. Mulcahy; Liam McAllan; Michelle A. Puchowicz; Joseph F. Pierre; Dave Bridges; Joan C. Han

doi:10.1038/s41467-022-33840-6

Nature Communications (Oct 2022)

Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue

Erin J. Stephenson,
Amanda S. Stayton,
Aarti Sethuraman,
Prahlad K. Rao,
Alice Meyer,
Charles Klazer Gomes,
Molly C. Mulcahy,
Liam McAllan,
Michelle A. Puchowicz,
Joseph F. Pierre,
Dave Bridges,
Joan C. Han

Affiliations

Erin J. Stephenson: Department of Anatomy, College of Graduate Studies, Midwestern University
Amanda S. Stayton: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center
Aarti Sethuraman: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center
Prahlad K. Rao: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center
Alice Meyer: Department of Anatomy, College of Graduate Studies, Midwestern University
Charles Klazer Gomes: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center
Molly C. Mulcahy: Department of Nutritional Sciences, University of Michigan School of Public Health
Liam McAllan: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center
Michelle A. Puchowicz: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center
Joseph F. Pierre: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center
Dave Bridges: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center
Joan C. Han: Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center

DOI: https://doi.org/10.1038/s41467-022-33840-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Dietary sugar intake may contribute to the development non-alcoholic fatty liver disease. Here the authors investigated the effects of chronic dietary sucrose on the liver-adipose-microbiome axis in mice, and report that sex is a moderating factor that influences sucrose-driven lipid storage in the liver and adipose tissue lipolysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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