Frontiers in Chemistry (Jun 2024)

Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI

  • Yue Wu,
  • Masafumi Minoshima,
  • Masafumi Minoshima,
  • Kazuya Kikuchi,
  • Kazuya Kikuchi

DOI
https://doi.org/10.3389/fchem.2024.1408509
Journal volume & issue
Vol. 12

Abstract

Read online

Perfluorocarbon-encapsulated silica nanoparticles possess attractive features such as biological inertness and favorable colloidal properties for bioimaging with fluorine magnetic resonance imaging (19F MRI). Herein, a series of elliptic shaped silica nanoparticles with perfluorocarbon liquid perfluoro-15-crown-5 ether as core (PFCE@SiO2) were synthesized using fluorinated surfactants N-(perfluorononylmethyl)-N,N,N-trimethylammonium chloride (C10-TAC) and N-(perfluoroheptylmethyl)-N,N,N-trimethylammonium chloride (C8-TAC). The nanoparticles are characterized to obtain elliptic core-shell structures. PFCE@SiO2 showed strong 19F NMR signals of the encapsulated PFCE, indicating the potential as a highly sensitive 19F MRI probe. These elliptic PFCE@SiO2 nanoparticles provide a new option of 19F MRI probe with a morphology different from conventional nanospheres.

Keywords