TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Guoliang Lyu; Yiting Guan; Chao Zhang; Le Zong; Lei Sun; Xiaoke Huang; Li Huang; Lijun Zhang; Xiao-Li Tian; Zhongjun Zhou; Wei Tao

doi:10.1038/s41467-018-04994-z

Nature Communications (Jul 2018)

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Guoliang Lyu,
Yiting Guan,
Chao Zhang,
Le Zong,
Lei Sun,
Xiaoke Huang,
Li Huang,
Lijun Zhang,
Xiao-Li Tian,
Zhongjun Zhou,
Wei Tao

Affiliations

Guoliang Lyu: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Yiting Guan: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Chao Zhang: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Le Zong: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Lei Sun: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Xiaoke Huang: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Li Huang: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Lijun Zhang: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Xiao-Li Tian: Department of Human Population Genetics, Human Aging Research Institute and School of Life Science, Nanchang University
Zhongjun Zhou: School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
Wei Tao: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University

DOI: https://doi.org/10.1038/s41467-018-04994-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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