Nature Communications (Oct 2022)
Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium
- Ivan Cokic,
- Shing Fai Chan,
- Xingmin Guan,
- Anand R. Nair,
- Hsin-Jung Yang,
- Ting Liu,
- Yinyin Chen,
- Diego Hernando,
- Jane Sykes,
- Richard Tang,
- John Butler,
- Alice Dohnalkova,
- Libor Kovarik,
- Robert Finney,
- Avinash Kali,
- Behzad Sharif,
- Louis S. Bouchard,
- Rajesh Gupta,
- Mayil Singaram Krishnam,
- Keyur Vora,
- Balaji Tamarappoo,
- Andrew G. Howarth,
- Andreas Kumar,
- Joseph Francis,
- Scott B. Reeder,
- John C. Wood,
- Frank S. Prato,
- Rohan Dharmakumar
Affiliations
- Ivan Cokic
- Cedars-Sinai Medical Center
- Shing Fai Chan
- Krannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular Institute
- Xingmin Guan
- Krannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular Institute
- Anand R. Nair
- Cedars-Sinai Medical Center
- Hsin-Jung Yang
- Cedars-Sinai Medical Center
- Ting Liu
- Cedars-Sinai Medical Center
- Yinyin Chen
- Cedars-Sinai Medical Center
- Diego Hernando
- University of Wisconsin
- Jane Sykes
- Lawson Health Research Institute, University of Western Ontario
- Richard Tang
- Krannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular Institute
- John Butler
- Lawson Health Research Institute, University of Western Ontario
- Alice Dohnalkova
- Pacific Northwest National Laboratory
- Libor Kovarik
- Pacific Northwest National Laboratory
- Robert Finney
- Cardio-Theranostics
- Avinash Kali
- Cedars-Sinai Medical Center
- Behzad Sharif
- Krannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular Institute
- Louis S. Bouchard
- University of California
- Rajesh Gupta
- University of Toledo
- Mayil Singaram Krishnam
- Stanford University
- Keyur Vora
- Krannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular Institute
- Balaji Tamarappoo
- Krannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular Institute
- Andrew G. Howarth
- University of Calgary
- Andreas Kumar
- Northern Ontario School of Medicine
- Joseph Francis
- Louisiana State University
- Scott B. Reeder
- University of Wisconsin
- John C. Wood
- University of Southern California
- Frank S. Prato
- Lawson Health Research Institute, University of Western Ontario
- Rohan Dharmakumar
- Krannert Cardiovascular Research Center, Indiana University School of Medicine/IU Health Cardiovascular Institute
- DOI
- https://doi.org/10.1038/s41467-022-33776-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
It is unclear why hemorrhagic myocardial infarctions (hMI) are destined for adverse outcomes. Here, the authors show that hMI drives fatty degeneration of infarct territories and contributes to adverse remodeling of the heart, which can be mitigated via timely depletion of iron within the hMI zone.
