Differences in birth weight between immigrants’ and natives’ children in Europe and Australia: a LifeCycle comparative observational cohort study
Martine Vrijheid,
John Wright,
Luca Ronfani,
Marie-Aline Charles,
Eva Corpeleijn,
Vincent Jaddoe,
Marisa Rebagliato,
Tanja G M Vrijkotte,
Rae-Chi Huang,
Lidia Panico,
Tiffany C Yang,
Loreto Santa Marina Rodriguez,
Sandra Florian,
Mathieu Ichou,
Stéphanie Pinel-Jacquemin,
Margreet W Harskamp-van Ginkel,
Jennie Carson,
Mikel Subiza-Pérez,
Sílvia Fernández-Barrés,
Marloes Cardol,
Elena Isaevska,
Chiara Moccia,
Marjolein N Kooijman,
Ellis Voerman,
Marieke Welten,
Elena Spada,
Andrea Beneito
Affiliations
Martine Vrijheid
ISGlobal, Barcelona, Spain
John Wright
Bradford Teaching Hospitals NHS Foundation Trust, Bradford Institute for Health Research, Bradford, UK
Luca Ronfani
Clinical Epidemiology and Public Health Research Unit, Istituto di Ricovero e Cura a Carattere Scientifico materno infantile Burlo Garofolo, Trieste, Italy
Marie-Aline Charles
Inserm and INED Joint Research Group, Paris, France
Eva Corpeleijn
Department of Epidemiology, GECKO Drenthe Cohort, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Vincent Jaddoe
The Generation R Study Group, University Medical Center, Erasmus Medical Center, Rotterdam, The Netherlands
Marisa Rebagliato
Predepartamental Unit of Medicine, Science Health Faculty, Universitat Jaume I, Castello de la Plana, Comunitat Valenciana, Spain
Tanja G M Vrijkotte
Department of Public Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Reproduction and Development Research Institute, Amsterdam, The Netherlands
Rae-Chi Huang
Nutrition and Health Innovation Research Institute, Edith Cowan University School of Medical and Health Sciences, Perth, Western Australia, Australia
Lidia Panico
French National Institute for Demographic Studies, INED, Paris, France
Tiffany C Yang
Bradford Teaching Hospitals NHS Foundation Trust, Bradford Institute for Health Research, Bradford, UK
Loreto Santa Marina Rodriguez
Group of Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, San Sebastián, Spain
Sandra Florian
French National Institute for Demographic Studies, INED, Paris, France
Mathieu Ichou
French National Institute for Demographic Studies, INED, Paris, France
Stéphanie Pinel-Jacquemin
UMR5193, LISST-CERS, Université Toulouse Jean Jaurès, Toulouse, France
Margreet W Harskamp-van Ginkel
Department of Public Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health Research Institute, Reproduction and Development Research Institute, Amsterdam, The Netherlands
Jennie Carson
Telethon Kids Institute, School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia
Mikel Subiza-Pérez
Group of Environmental Epidemiology and Child Development, Biodonostia Health Research Institute, San Sebastián, Spain
Sílvia Fernández-Barrés
ISGlobal, Barcelona, Spain
Marloes Cardol
Department of Epidemiology, GECKO Drenthe Cohort, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Elena Isaevska
Dipartimento di Scienze Mediche, Universita degli Studi di Torino, Torino, Italy
Chiara Moccia
Department of Medical Sciences, University of Turin, Torino, Italy
Marjolein N Kooijman
The Generation R Study Group, University Medical Center, Erasmus Medical Center, Rotterdam, The Netherlands
Ellis Voerman
The Generation R Study Group, University Medical Center, Erasmus Medical Center, Rotterdam, The Netherlands
Marieke Welten
The Generation R Study Group, University Medical Center, Erasmus Medical Center, Rotterdam, The Netherlands
Elena Spada
Unit of Epidemiology, Meyer Children`s University Hospital, Florence, Italy
Andrea Beneito
Joint Research Unit in Epidemiology, Environment and Health, FISABIO, Valencia, Spain
Objective Research on adults has identified an immigrant health advantage, known as the ‘immigrant health paradox’, by which migrants exhibit better health outcomes than natives. Is this health advantage transferred from parents to children in the form of higher birth weight relative to children of natives?Setting Western Europe and Australia.Participants We use data from nine birth cohorts participating in the LifeCycle Project, including five studies with large samples of immigrants’ children: Etude Longitudinale Française depuis l’Enfance—France (N=12 494), the Raine Study—Australia (N=2283), Born in Bradford—UK (N=4132), Amsterdam Born Children and their Development study—Netherlands (N=4030) and the Generation R study—Netherlands (N=4877). We include male and female babies born to immigrant and native parents.Primary and secondary outcome measures The primary outcome is birth weight measured in grams. Different specifications were tested: birth weight as a continuous variable including all births (DV1), the same variable but excluding babies born with over 4500 g (DV2), low birth weight as a 0–1 binary variable (1=birth weight below 2500 g) (DV3). Results using these three measures were similar, only results using DV1 are presented. Parental migration status is measured in four categories: both parents natives, both born abroad, only mother born abroad and only father born abroad.Results Two patterns in children’s birth weight by parental migration status emerged: higher birth weight among children of immigrants in France (+12 g, p<0.10) and Australia (+40 g, p<0.10) and lower birth weight among children of immigrants in the UK (−82 g, p<0.05) and the Netherlands (−80 g and −73 g, p<0.001) compared with natives’ children. Smoking during pregnancy emerged as a mechanism explaining some of the birth weight gaps between children of immigrants and natives.Conclusion The immigrant health advantage is not universally transferred to children in the form of higher birth weight in all host countries. Further research should investigate whether this cross-national variation is due to differences in immigrant communities, social and healthcare contexts across host countries.