DNA engineered micromotors powered by metal nanoparticles for motion based cellphone diagnostics

Mohamed Shehata Draz; Kamyar Mehrabi Kochehbyoki; Anish Vasan; Dheerendranath Battalapalli; Aparna Sreeram; Manoj Kumar Kanakasabapathy; Shantanu Kallakuri; Athe Tsibris; Daniel R. Kuritzkes; Hadi Shafiee

doi:10.1038/s41467-018-06727-8

Nature Communications (Oct 2018)

DNA engineered micromotors powered by metal nanoparticles for motion based cellphone diagnostics

Mohamed Shehata Draz,
Kamyar Mehrabi Kochehbyoki,
Anish Vasan,
Dheerendranath Battalapalli,
Aparna Sreeram,
Manoj Kumar Kanakasabapathy,
Shantanu Kallakuri,
Athe Tsibris,
Daniel R. Kuritzkes,
Hadi Shafiee

Affiliations

Mohamed Shehata Draz: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Kamyar Mehrabi Kochehbyoki: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Anish Vasan: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Dheerendranath Battalapalli: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Aparna Sreeram: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Manoj Kumar Kanakasabapathy: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Shantanu Kallakuri: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Athe Tsibris: Department of Medicine, Harvard Medical School
Daniel R. Kuritzkes: Department of Medicine, Harvard Medical School
Hadi Shafiee: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-06727-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Micromotors have a range of potential healthcare applications. Here, the authors describe the development of a metal nanoparticle DNA micromotor which can be used to detect human HIV-1 by a change in the motion of the micromotors, monitored by cell phone camera, triggered by binding of HIV-1 RNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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