PLoS ONE (Jan 2013)

Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study.

  • Camille Legeai,
  • Corinne Vigouroux,
  • Jean-Claude Souberbielle,
  • Olivier Bouchaud,
  • Faroudy Boufassa,
  • Jean-Philippe Bastard,
  • Robert Carlier,
  • Jacqueline Capeau,
  • Cécile Goujard,
  • Laurence Meyer,
  • Jean-Paul Viard,
  • ANRS-COPANA Cohort Study Group

DOI
https://doi.org/10.1371/journal.pone.0074868
Journal volume & issue
Vol. 8, no. 9
p. e74868

Abstract

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ObjectivesLow 25(OH)D has been associated with dyslipidemia, insulin resistance and inflammation in both general and HIV-infected (mostly treated) populations. We investigated these associations in antiretroviral-naïve HIV-infected persons.DesignWe measured plasma 25(OH)D, metabolic, immunologic and inflammatory markers in 355 persons (204 Whites, 151 Blacks) at enrollment in the ANRS COPANA cohort.Methods25(OH)D levels were categorized Results25(OH)D insufficiency (ConclusionsSevere vitamin D deficiency was associated with low CD4 counts and increased markers of inflammation in ARV-naïve HIV-infected persons.