Nature Communications (Dec 2019)

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

  • Zhiyong Wang,
  • Victoria H. Wu,
  • Michael M. Allevato,
  • Mara Gilardi,
  • Yudou He,
  • Juan Luis Callejas-Valera,
  • Lynn Vitale-Cross,
  • Daniel Martin,
  • Panomwat Amornphimoltham,
  • James Mcdermott,
  • Bryan S. Yung,
  • Yusuke Goto,
  • Alfredo A. Molinolo,
  • Andrew B. Sharabi,
  • Ezra E. W. Cohen,
  • Qianming Chen,
  • J. Guy Lyons,
  • Ludmil B. Alexandrov,
  • J. Silvio Gutkind

DOI
https://doi.org/10.1038/s41467-019-13471-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report a high response rate to anti-CTLA-4 therapy.